基于淋巴细胞计数的分层尿液LAM检测改善结核病诊断的新策略——数据表1

数据集获取（Figshare）

• 源站标题：Data Sheet 1_A new strategy improving TB diagnosis: stratified urine LAM test based on lymphocyte counts.docx
• DOI：10.3389/fcimb.2025.1498651.s001
• 发布日期：2025-02-20
• 文件数：1 个
• 文件总体积：215.32 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_A_new_strategy_improving_TB_diagnosis_stratified_urine_LAM_test_based_on_lymphocyte_counts_docx/28449458

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curl -L -o "Data Sheet 1_A new strategy improving TB diagnosis: stratified urine LAM test based on lymphocyte counts.docx" "https://ndownloader.figshare.com/files/52485557"

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• Data Sheet 1_A new strategy improving TB diagnosis: stratified urine LAM test based on lymphocyte counts.docx（215.32 KB）

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数据说明

BackgroundTraditional lipoarabinomannan tests have limited sensitivity in HIV-negative individuals. Our aims were to compare chemiluminescence-based LAM (AIMLAM) and other diagnostic modalities in HIV-negative patients and to explore whether lymphocyte counts impact the sensitivity and costs of AIMLAM.
MethodsThis is a prospective, cross-sectional, diagnostic accuracy study. Participants underwent testing with sputum acid-fast bacilli, sputum culture, GeneXpert, and AIMLAM. Their diagnostic efficiency and cost-effectiveness alone or under different lymphocyte count categories was evaluated.
ResultsUsing MRS as a reference, the sensitivities of different diagnostic methods were as follows: sputum smear 27.43%, sputum culture 45.13%, GeneXpert 74.34%, and AIMLAM 71.68%. Patients with lymphocyte counts 9/L were significantly more likely to have a positive AIMLAM result (OR = 9.431, 95% CI: 2.659–33.447, P = 0.001). The sensitivity of AIMLAM in patients with lymphocyte counts 9/L reached 93.02%. The overall cost of AIMLAM to detect a positive TB case was $129.82, lower than sputum culture ($136.10) and GeneXpert ($180.27). For patients with lymphocyte counts 9/L, the cost of AIMLAM was further reduced to $67.84 (a 47.74% decrease), which was lower than GeneXpert ($111.65) and sputum culture ($94.28).
ConclusionAIMLAM showed promising diagnostic performance in HIV-negative patients. Stratifying patients using lymphocyte cell counting lifted the sensitivity and lowered the cost of LAM, offering a novel diagnostic strategy for tuberculosis in resource-limited settings.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fcimb.2025.1498651.s001（source: https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_A_new_strategy_improving_TB_diagnosis_stratified_urine_LAM_test_based_on_lymphocyte_counts_docx/28449458）。