结核病治疗依从性干预措施与结果：随机对照试验和观察性研究的系统综述与荟萃分析

数据集获取（Figshare）

• 源站标题：Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies
• DOI：10.1371/journal.pmed.1002595
• 发布日期：2018-07-03
• 文件数：87 个
• 文件总体积：34.30 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Adherence_interventions_and_outcomes_of_tuberculosis_treatment_A_systematic_review_and_meta-analysis_of_trials_and_observational_studies/6737438

命令行下载

curl -L -o "pmed.1002595.s001.doc" "https://ndownloader.figshare.com/files/12286307"
curl -L -o "pmed.1002595.s002.doc" "https://ndownloader.figshare.com/files/12286310"
curl -L -o "pmed.1002595.s003.docx" "https://ndownloader.figshare.com/files/12286313"
curl -L -o "pmed.1002595.s004.docx" "https://ndownloader.figshare.com/files/12286316"
curl -L -o "pmed.1002595.s005.docx" "https://ndownloader.figshare.com/files/12286319"
curl -L -o "pmed.1002595.s006.tif" "https://ndownloader.figshare.com/files/12286322"
curl -L -o "pmed.1002595.s007.tif" "https://ndownloader.figshare.com/files/12286325"
curl -L -o "pmed.1002595.s008.tif" "https://ndownloader.figshare.com/files/12286328"

文件清单

• pmed.1002595.s001.doc（66.05 KB）
• pmed.1002595.s002.doc（50.18 KB）
• pmed.1002595.s003.docx（71.09 KB）
• pmed.1002595.s004.docx（46.81 KB）
• pmed.1002595.s005.docx（61.55 KB）
• pmed.1002595.s006.tif（433.36 KB）
• pmed.1002595.s007.tif（1.08 MB）
• pmed.1002595.s008.tif（205.94 KB）
• pmed.1002595.s009.tif（495.20 KB）
• pmed.1002595.s010.tif（229.67 KB）
• pmed.1002595.s011.tif（694.13 KB）
• pmed.1002595.s012.tif（229.48 KB）
• pmed.1002595.s013.tif（546.20 KB）
• pmed.1002595.s014.tif（196.27 KB）
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• pmed.1002595.s016.tif（235.05 KB）
• pmed.1002595.s017.tif（515.83 KB）
• pmed.1002595.s018.tif（504.18 KB）
• pmed.1002595.s019.tif（297.30 KB）
• pmed.1002595.s020.tif（355.03 KB）

文件总体积 34.30 MB（源站 API 实测）。

数据说明

Background
Incomplete adherence to tuberculosis (TB) treatment increases the risk of delayed culture conversion with continued transmission in the community, as well as treatment failure, relapse, and development or amplification of drug resistance. We conducted a systematic review and meta-analysis of adherence interventions, including directly observed therapy (DOT), to determine which approaches lead to improved TB treatment outcomes.
Methods and findings
We systematically reviewed Medline as well as the references of published review articles for relevant studies of adherence to multidrug treatment of both drug-susceptible and drug-resistant TB through February 3, 2018. We included randomized controlled trials (RCTs) as well as prospective and retrospective cohort studies (CSs) with an internal or external control group that evaluated any adherence intervention and conducted a meta-analysis of their impact on TB treatment outcomes. Our search identified 7,729 articles, of which 129 met the inclusion criteria for quantitative analysis. Seven adherence categories were identified, including DOT offered by different providers and at various locations, reminders and tracers, incentives and enablers, patient education, digital technologies (short message services [SMSs] via mobile phones and video-observed therapy [VOT]), staff education, and combinations of these interventions. When compared with DOT alone, self-administered therapy (SAT) was associated with lower rates of treatment success (CS: risk ratio [RR] 0.81, 95% CI 0.73–0.89; RCT: RR 0.94, 95% CI 0.89–0.98), adherence (CS: RR 0.83, 95% CI 0.75–0.93), and sputum smear conversion (RCT: RR 0.92, 95% CI 0.87–0.98) as well as higher rates of development of drug resistance (CS: RR 4.19, 95% CI 2.34–7.49). When compared to DOT provided by healthcare providers, DOT provided by family members was associated with a lower rate of adherence (CS: RR 0.86, 95% CI 0.79–0.94). DOT delivery in the community versus at the clinic was associated with a higher rate of treatment success (CS: RR 1.08, 95% CI 1.01–1.15) and sputum conversion at the end of two months (CS: RR 1.05, 95% CI 1.02–1.08) as well as lower rates of trea

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pmed.1002595（source: https://plos.figshare.com/articles/dataset/Adherence_interventions_and_outcomes_of_tuberculosis_treatment_A_systematic_review_and_meta-analysis_of_trials_and_observational_studies/6737438）。