脑型疟疾肠内喂养时机随机试验

数据集获取（Figshare）

• 源站标题：Timing of Enteral Feeding in Cerebral Malaria in Resource-Poor Settings: A Randomized Trial
• DOI：10.1371/journal.pone.0027273
• 发布日期：2011-11-16
• 文件数：2 个
• 文件总体积：300.03 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Timing_of_Enteral_Feeding_in_Cerebral_Malaria_in_Resource_Poor_Settings_A_Randomized_Trial/131301

命令行下载

curl -L -o "Protocol_S1.doc" "https://ndownloader.figshare.com/files/360790"
curl -L -o "Checklist_S1.doc" "https://ndownloader.figshare.com/files/360931"

文件清单

• Protocol_S1.doc（76.29 KB）
• Checklist_S1.doc（223.74 KB）

文件总体积 300.03 KB（源站 API 实测）。

数据说明

Background
Early start of enteral feeding is an established treatment strategy in intubated patients in intensive care since it reduces invasive bacterial infections and length of hospital stay. There is equipoise whether early enteral feeding is also beneficial in non-intubated patients with cerebral malaria in resource poor settings. We hypothesized that the risk of aspiration pneumonia might outweigh the potential benefits of earlier recovery and prevention of hypoglycaemia.
Method and Findings
A randomized trial of early (day of admission) versus late (after 60 hours in adults or 36 hours in children) start of enteral feeding was undertaken in patients with cerebral malaria in Chittagong, Bangladesh from May 2008 to August 2009. The primary outcome measures were incidence of aspiration pneumonia, hypoglycaemia and coma recovery time. The trial was terminated after inclusion of 56 patients because of a high incidence of aspiration pneumonia in the early feeding group (9/27 (33%)), compared to the late feeding group (0/29 (0%)), p = 0.001). One patient in the late feeding group, and none in the early group, had hypoglycaemia during admission. There was no significant difference in overall mortality (9/27 (33%) vs 6/29 (21%), p = 0.370), but mortality was 5/9 (56%) in patients with aspiration pneumonia.
Conclusions
In conclusion, early start of enteral feeding is detrimental in non-intubated patients with cerebral malaria in many resource-poor settings. Evidence gathered in resource rich settings is not necessarily transferable to resource-poor settings.
Trial Registration
Controlled-Trials.com ISRCTN57488577

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0027273（source: https://plos.figshare.com/articles/dataset/Timing_of_Enteral_Feeding_in_Cerebral_Malaria_in_Resource_Poor_Settings_A_Randomized_Trial/131301）。