巴洛沙韦酯在免疫正常和免疫低下小鼠模型中抑制流感病毒复制及治疗效果研究数据集

资源简介

巴洛沙韦酯在免疫正常和免疫低下小鼠模型中抑制流感病毒复制及治疗效果研究数据集

【数据集背景】

本数据集源站标题为《Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models》。配套论文《Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models》发表于 PLOS ONE（2019），DOI：10.1371/journal.pone.0217307。源站首次发布：2019-05-20。

【数据内容】

源站原始描述：Baloxavir marboxil (BXM) is an orally available small molecule inhibitor of cap-dependent endonuclease (CEN), an essential enzyme in the initiation of mRNA synthesis of influenza viruses. In the present study, we evaluated the efficacy of BXM against influenza virus infection in mouse models. Single-day oral administration of BXM completely prevented mortality due to infection with influenza A and B virus in mice. Moreover, 5-day repeated administration of BXM was more effective for reducing mor…

【数据结构与技术规格】

文件数 11 个，合计 27.17 MB。pone.0217307.s001.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，27.06 KB。pone.0217307.s002.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，26.98 KB。pone.0217307.s003.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，27.27 KB。数据集 DOI：10.1371/journal.pone.0217307。

【主题与分类】

源站学科分类：Biochemistry、Medicine、Microbiology、Pharmacology、Biotechnology、Immunology。主题标签：novel cap-dependent endonuclease inhibitor potently、immunocompromised mouse model、OSP、virus titer、influenza virus infection、96 hours post infection、influenza virus replication、immunocompromised mouse models Baloxavir marboxil、body weight loss、BXM。

【适用方向】

源站学科分类标注为 Biochemistry、Medicine、Microbiology、Pharmacology、Biotechnology、Immunology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Baloxavir_marboxil_a_novel_cap-dependent_endonuclease_inhibitor_potently_suppresses_influenza_virus_replication_and_represents_therapeutic_effects_in_both_immunocompetent_and_immunocompromised_mouse_models/8154875

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Fukao, Keita; Ando, Yoshinori; Noshi, Takeshi; Kitano, Mitsutaka; Noda, Takahiro; Kawai, Makoto; et al. (2019). Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompro…

【使用注意】

· 源站最后修改于 2023-05-30，引用时请注意版本时效。