VISITECT CD4半定量测试用于晚期HIV疾病筛查的诊断性能和可用性

数据集获取（Figshare）

• 源站标题：Diagnostic performance and usability of the VISITECT CD4 semi-quantitative test for advanced HIV disease screening
• DOI：10.1371/journal.pone.0230453
• 发布日期：2020-04-03
• 文件数：2 个
• 文件总体积：6.65 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Diagnostic_performance_and_usability_of_the_VISITECT_CD4_semi-quantitative_test_for_advanced_HIV_disease_screening/12079464

命令行下载

curl -L -o "pone.0230453.s001.tif" "https://ndownloader.figshare.com/files/22207068"
curl -L -o "pone.0230453.s002.tif" "https://ndownloader.figshare.com/files/22207074"

文件清单

• pone.0230453.s001.tif（5.64 MB）
• pone.0230453.s002.tif（1.01 MB）

文件总体积 6.65 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
In sub-Saharan Africa, a third of people starting antiretroviral therapy and majority of patients returning to HIV-care after disengagement, present with advanced HIV disease (ADH), and are at high risk of mortality. Simplified and more affordable point-of-care (POC) diagnostics are required to increase access to prompt CD4 cell count screening for ambulatory and asymptomatic patients. The Visitect CD4 Lateral Flow Assay (LFA) is a disposable POC test, providing a visually interpreted result of above or below 200 CD4cells/mm3. This study evaluated the diagnostic performance of this index test.
Methods
Consenting patients above 18years of age and eligible for CD4 testing were enrolled in Nsanje district hospital (Malawi), Gutu mission hospital (Zimbabwe) and Centre hopitalier de Kabinda (DRC). A total of 708 venous blood samples were tested in the index test and in the BD FACSCount assay (reference test method) in the laboratories (Phase 1) to determine diagnostic accuracy. A total of 433 finger-prick (FP) samples were tested on the index test at POC by clinicians (Phase 2) and a self-completed questionnaire was administered to all testers to explore usability of the index test.
Results
Among 708 patients, 67.2% were female and median CD4 was 297cells/mm3. The sensitivity of the Visitect CD4 LFA using venous blood in the laboratory was 95.0% [95% CI: 91.3–97.5] and specificity was 81.9% [95% CI: 78.2–85.2%]. Using FP samples, the sensitivity of the Visitect CD4 LFA was 98.3% [95% CI: 95.0–99.6] and specificity was 77.2% [95% CI: 71.6–82.2%]. Usability of the Visitect CD4 LFA was high across the study sites with 97% successfully completed tests. Due to the required specific multiple incubation and procedural steps during the Visitect CD4 LFA testing, few health workers (7/26) were not confident to manage testing whilst multi-tasking in their clinical work.
Conclusions
Visitect CD4 LFA is a promising test for decentralized CD4 screening in resource-limited settings, without access to CD4 testing and and it can trigger prompt management of patients with AHD. Lay health cadres should be considered to conduct Visitect CD4 LFA testing in PHCs as well as coor

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0230453（source: https://plos.figshare.com/articles/dataset/Diagnostic_performance_and_usability_of_the_VISITECT_CD4_semi-quantitative_test_for_advanced_HIV_disease_screening/12079464）。