氯己定诱导的艰难梭菌孢子杀灭活性数据集

数据集获取（Figshare）

• 源站标题：Induced Sporicidal Activity of Chlorhexidine against <i>Clostridium difficile</i> Spores under Altered Physical and Chemical Conditions
• DOI：10.1371/journal.pone.0123809
• 发布日期：2015-04-10
• 文件数：4 个
• 文件总体积：59.02 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Induced_Sporicidal_Activity_of_Chlorhexidine_against_Clostridium_difficile_Spores_under_Altered_Physical_and_Chemical_Conditions/1374806

命令行下载

curl -L -o "S1_Fig.xlsx" "https://ndownloader.figshare.com/files/2014229"
curl -L -o "S2_Fig.xlsx" "https://ndownloader.figshare.com/files/2014230"
curl -L -o "S3_Fig.xlsx" "https://ndownloader.figshare.com/files/2014231"
curl -L -o "S4_Fig.xlsx" "https://ndownloader.figshare.com/files/2014232"

文件清单

• S1_Fig.xlsx（18.76 KB）
• S2_Fig.xlsx（19.12 KB）
• S3_Fig.xlsx（10.31 KB）
• S4_Fig.xlsx（10.83 KB）

文件总体积 59.02 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
Chlorhexidine is a broad-spectrum antimicrobial commonly used to disinfect the skin of patients to reduce the risk of healthcare-associated infections. Because chlorhexidine is not sporicidal, it is not anticipated that it would have an impact on skin contamination with Clostridium difficile, the most important cause of healthcare-associated diarrhea. However, although chlorhexidine is not sporicidal as it is used in healthcare settings, it has been reported to kill spores of Bacillus species under altered physical and chemical conditions that disrupt the spore’s protective barriers (e.g., heat, ultrasonication, alcohol, or elevated pH). Here, we tested the hypothesis that similarly altered physical and chemical conditions result in enhanced sporicidal activity of chlorhexidine against C. difficile spores.
Principal Findings
C. difficile spores became susceptible to heat killing at 80°C within 15 minutes in the presence of chlorhexidine, as opposed to spores suspended in water which remained viable. The extent to which the spores were reduced was directly proportional to the concentration of chlorhexidine in solution, with no viable spores recovered after 15 minutes of incubation in 0.04%–0.0004% w/v chlorhexidine solutions at 80°C. Reduction of spores exposed to 4% w/v chlorhexidine solutions at moderate temperatures (37°C and 55°C) was enhanced by the presence of 70% ethanol. However, complete elimination of spores was not achieved until 3 hours of incubation at 55°C. Elevating the pH to ≥9.5 significantly enhanced the killing of spores in either aqueous or alcoholic chlorhexidine solutions.
Conclusions
Physical and chemical conditions that alter the protective barriers of C. difficile spores convey sporicidal activity to chlorhexidine. Further studies are necessary to identify additional agents that may allow chlorhexidine to reach its target within the spore.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0123809（source: https://plos.figshare.com/articles/dataset/Induced_Sporicidal_Activity_of_Chlorhexidine_against_Clostridium_difficile_Spores_under_Altered_Physical_and_Chemical_Conditions/1374806）。