刚果民主共和国非严重未分类发热儿童第3天随访策略的群组随机非劣效性试验

数据集获取（Figshare）

• 源站标题：Universal versus conditional day 3 follow-up for children with non-severe unclassified fever at the community level in the Democratic Republic of the Congo: A cluster-randomized, community-based non-inferiority trial
• DOI：10.1371/journal.pmed.1002552
• 发布日期：2018-04-17
• 文件数：4 个
• 文件总体积：496.73 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Universal_versus_conditional_day_3_follow-up_for_children_with_non-severe_unclassified_fever_at_the_community_level_in_the_Democratic_Republic_of_the_Congo_A_cluster-randomized_community-based_non-inferiority_trial/6149405

命令行下载

curl -L -o "S1 CONSORT Checklist.pdf" "https://ndownloader.figshare.com/files/11118038"
curl -L -o "S1 Table.docx" "https://ndownloader.figshare.com/files/11118041"
curl -L -o "S2 Table.docx" "https://ndownloader.figshare.com/files/11118044"
curl -L -o "S1 Protocol.pdf" "https://ndownloader.figshare.com/files/11118047"

文件清单

• S1 CONSORT Checklist.pdf（64.76 KB）
• S1 Table.docx（16.93 KB）
• S2 Table.docx（13.88 KB）
• S1 Protocol.pdf（401.16 KB）

文件总体积 496.73 KB（源站 API 实测）。

数据说明

Background
The World Health Organization’s integrated community case management (iCCM) guidelines recommend that all children presenting with uncomplicated fever and no danger signs return for follow-up on day 3 following the initial consultation on day 1. Such fevers often resolve rapidly, however, and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aimed to determine if a conditional follow-up visit was non-inferior to a universal follow-up visit for these children.
Methods and findings
We conducted a cluster-randomized, community-based non-inferiority trial among children 2–59 months old presenting to community health workers (CHWs) with non-severe unclassified fever in Tanganyika Province, Democratic Republic of the Congo. Clusters (n = 28) of CHWs were randomized to advise caregivers to either (1) return for a follow-up visit on day 3 following the initial consultation on day 1, regardless of illness resolution (as per current WHO guidelines; universal follow-up group) or (2) return for a follow-up visit on day 3 only if illness continued (conditional follow-up group). Children in both arms were assessed again at day 8, and classified as a clinical failure if fever (caregiver-reported), malaria, diarrhea, pneumonia, or decline of health status (development of danger signs, hospitalization, or death) was noted (failure definition 1). Alternative failure definitions were examined, whereby caregiver-reported fever was first restricted to caregiver-reported fever of at least 3 days (failure definition 2) and then replaced with fever measured via axillary temperature (failure definition 3). Study participants, providers, and investigators were not masked. Among 4,434 enrolled children, 4,141 (93.4%) met the per-protocol definition of receipt of the arm-specific advice from the CHW and a timely day 8 assessment (universal follow-up group: 2,210; conditional follow-up group: 1,931). Failure was similar (difference: –0.7%) in the conditional follow-up group (n = 188, 9.7%) compared to the universal follow-up group (n = 230, 10.4%); however, the upper bound of a 1-sided 95% confidence interval around this diffe

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pmed.1002552（source: https://plos.figshare.com/articles/dataset/Universal_versus_conditional_day_3_follow-up_for_children_with_non-severe_unclassified_fever_at_the_community_level_in_the_Democratic_Republic_of_the_Congo_A_cluster-randomized_community-based_non-inferiority_trial/6149405）。