大鼠中心静脉导管模型研究长期细菌生物膜形成及相关急慢性感染

数据集获取（Figshare）

• 源站标题：A Rat Model of Central Venous Catheter to Study Establishment of Long-Term Bacterial Biofilm and Related Acute and Chronic Infections
• DOI：10.1371/journal.pone.0037281
• 发布日期：2012-05-16
• 文件数：9 个
• 文件总体积：18.36 MB
• 源站页面：https://plos.figshare.com/articles/dataset/A_Rat_Model_of_Central_Venous_Catheter_to_Study_Establishment_of_Long_Term_Bacterial_Biofilm_and_Related_Acute_and_Chronic_Infections/125134

命令行下载

curl -L -o "Figure_S1.tif" "https://ndownloader.figshare.com/files/329866"
curl -L -o "Figure_S2.tif" "https://ndownloader.figshare.com/files/329916"
curl -L -o "Figure_S3.tif" "https://ndownloader.figshare.com/files/329979"
curl -L -o "Figure_S4.tif" "https://ndownloader.figshare.com/files/330060"
curl -L -o "Figure_S5.tif" "https://ndownloader.figshare.com/files/330106"
curl -L -o "Figure_S6.tif" "https://ndownloader.figshare.com/files/330144"
curl -L -o "Figure_S7.tif" "https://ndownloader.figshare.com/files/330180"
curl -L -o "Table_S1.docx" "https://ndownloader.figshare.com/files/330220"

文件清单

• Figure_S1.tif（272.15 KB）
• Figure_S2.tif（8.05 MB）
• Figure_S3.tif（4.16 MB）
• Figure_S4.tif（2.80 MB）
• Figure_S5.tif（684.75 KB）
• Figure_S6.tif（604.93 KB）
• Figure_S7.tif（1.68 MB）
• Table_S1.docx（63.05 KB）
• Table_S2.docx（48.72 KB）

文件总体积 18.36 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Formation of resilient biofilms on medical devices colonized by pathogenic microorganisms is a major cause of health-care associated infection. While in vitro biofilm analyses led to promising anti-biofilm approaches, little is known about their translation to in vivo situations and on host contribution to the in vivo dynamics of infections on medical devices. Here we have developed an in vivo model of long-term bacterial biofilm infections in a pediatric totally implantable venous access port (TIVAP) surgically placed in adult rats. Using non-invasive and quantitative bioluminescence, we studied TIVAP contamination by clinically relevant pathogens, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis, and we demonstrated that TIVAP bacterial populations display typical biofilm phenotypes. In our study, we showed that immunocompetent rats were able to control the colonization and clear the bloodstream infection except for up to 30% that suffered systemic infection and death whereas none of the immunosuppressed rats survived the infection. Besides, we mimicked some clinically relevant TIVAP associated complications such as port-pocket infection and hematogenous route of colonization. Finally, by assessing an optimized antibiotic lock therapy, we established that our in vivo model enables to assess innovative therapeutic strategies against bacterial biofilm infections.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0037281（source: https://plos.figshare.com/articles/dataset/A_Rat_Model_of_Central_Venous_Catheter_to_Study_Establishment_of_Long_Term_Bacterial_Biofilm_and_Related_Acute_and_Chronic_Infections/125134）。