类风湿关节炎甲氨蝶呤反应预测模型数据集

数据集获取（Figshare）

• 源站标题：Development and validation of a prognostic multivariable model to predict insufficient clinical response to methotrexate in rheumatoid arthritis
• DOI：10.1371/journal.pone.0208534
• 发布日期：2018-12-10
• 文件数：2 个
• 文件总体积：98.42 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Development_and_validation_of_a_prognostic_multivariable_model_to_predict_insufficient_clinical_response_to_methotrexate_in_rheumatoid_arthritis/7443950

命令行下载

curl -L -o "pone.0208534.s001.sav" "https://ndownloader.figshare.com/files/13779950"
curl -L -o "pone.0208534.s002.docx" "https://ndownloader.figshare.com/files/13779953"

文件清单

• pone.0208534.s001.sav（84.98 KB）
• pone.0208534.s002.docx（13.44 KB）

文件总体积 98.42 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Objective
The objective was to predict insufficient response to 3 months methotrexate (MTX) in DMARD naïve rheumatoid arthritis patients.
Methods
A Multivariable logistic regression model of rheumatoid arthritis patients starting MTX was developed in a derivation cohort with 285 patients starting MTX in a clinical multicentre, stratified single-blinded trial, performed in seven secondary care clinics and a tertiary care clinic. The model was validated in a validation cohort with 102 patients starting MTX at a tertiary care clinic. Outcome was insufficient response (disease activity score (DAS)28 >3.2) after 3 months of MTX treatment. Clinical characteristics, lifestyle variables, genetic and metabolic biomarkers were determined at baseline in both cohorts. These variables were dichotomized and used to construct a multivariable prediction model with backward logistic regression analysis.
Results
The prediction model for insufficient response in the derivation cohort, included: DAS28>5.1, Health Assessment Questionnaire>0.6, current smoking, BMI>25 kg/m2, ABCB1 rs1045642 genotype, ABCC3 rs4793665 genotype, and erythrocyte-folateConclusions
A prognostics prediction model for insufficient response to MTX in 2 prospective RA cohorts by combining genetic, metabolic, clinical and lifestyle variables was developed and validated. This model satisfactorily identified RA patients with high risk of insufficient response to MTX.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0208534（source: https://plos.figshare.com/articles/dataset/Development_and_validation_of_a_prognostic_multivariable_model_to_predict_insufficient_clinical_response_to_methotrexate_in_rheumatoid_arthritis/7443950）。