预防急性内科疾病住院患者静脉血栓栓塞的多方面干预：一项多中心整群随机试验

数据集获取（Figshare）

• 源站标题：Multifaceted Intervention to Prevent Venous Thromboembolism in Patients Hospitalized for Acute Medical Illness: A Multicenter Cluster-Randomized Trial
• DOI：10.1371/journal.pone.0154832
• 发布日期：2016-05-26
• 文件数：15 个
• 文件总体积：4.15 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Multifaceted_Intervention_to_Prevent_Venous_Thromboembolism_in_Patients_Hospitalized_for_Acute_Medical_Illness_A_Multicenter_Cluster-Randomized_Trial/3933156

命令行下载

curl -L -o "S1 CONSORT Checklist.DOCX" "https://ndownloader.figshare.com/files/6153357"
curl -L -o "S1 Poster.PDF" "https://ndownloader.figshare.com/files/6153384"
curl -L -o "S2 Poster.PDF" "https://ndownloader.figshare.com/files/6153396"
curl -L -o "S1 Protocol.DOCX" "https://ndownloader.figshare.com/files/6153417"
curl -L -o "S1 Statistical Analysis Plan.PDF" "https://ndownloader.figshare.com/files/6153429"
curl -L -o "S1 Table.DOC" "https://ndownloader.figshare.com/files/6153444"
curl -L -o "S2 Table.DOC" "https://ndownloader.figshare.com/files/6153471"
curl -L -o "S3 Table.DOC" "https://ndownloader.figshare.com/files/6153492"

文件清单

• S1 CONSORT Checklist.DOCX（32.35 KB）
• S1 Poster.PDF（300.15 KB）
• S2 Poster.PDF（2.54 MB）
• S1 Protocol.DOCX（102.95 KB）
• S1 Statistical Analysis Plan.PDF（608.15 KB）
• S1 Table.DOC（96.26 KB）
• S2 Table.DOC（101.89 KB）
• S3 Table.DOC（45.57 KB）
• S4 Table.DOC（43.52 KB）
• S5 Table.DOC（49.66 KB）
• S6 Table.DOC（47.10 KB）
• S7 Table.DOC（51.71 KB）
• S8 Table.DOC（47.10 KB）
• S9 Table.DOC（47.62 KB）
• S10 Table.DOC（40.96 KB）

文件总体积 4.15 MB（源站 API 实测）。

数据说明

Background
Misuse of thromboprophylaxis may increase preventable complications for hospitalized medical patients.
Objectives
To assess the net clinical benefit of a multifaceted intervention in emergency wards (educational lectures, posters, pocket cards, computerized clinical decision support systems and, where feasible, electronic reminders) for the prevention of venous thromboembolism.
Patients/Methods
Prospective cluster-randomized trial in 27 hospitals. After a pre-intervention period, centers were randomized as either intervention (n = 13) or control (n = 14). All patients over 40 years old, admitted to the emergency room, and hospitalized in a medical ward were included, totaling 1,402 (712 intervention and 690 control) and 15,351 (8,359 intervention and 6,992 control) in the pre-intervention and intervention periods, respectively.
Results
Symptomatic venous thromboembolism or major bleeding (primary outcome) occurred at 3 months in 3.1% and 3.2% of patients in the intervention and control groups, respectively (adjusted odds ratio: 1.02 [95% confidence interval: 0.78–1.34]). The rates of thromboembolism (1.9% vs. 1.9%), major bleedings (1.2% vs. 1.3%), and mortality (11.3% vs. 11.1%) did not differ between the groups. Between the pre-intervention and intervention periods, the proportion of patients who received prophylactic anticoagulant treatment more steeply increased in the intervention group (from 35.0% to 48.2%: +13.2%) than the control (40.7% to 44.1%: +3.4%), while the rate of adequate thromboprophylaxis remained stable in both groups (52.4% to 50.9%: -1.5%; 49.1% to 48.8%: -0.3%).
Conclusions
Our intervention neither improved adequate prophylaxis nor reduced the rates of clinical events. New strategies are required to improve thromboembolism prevention for hospitalized medical patients.
Trial Registration
ClinicalTrials.gov NCT01212393

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0154832（source: https://plos.figshare.com/articles/dataset/Multifaceted_Intervention_to_Prevent_Venous_Thromboembolism_in_Patients_Hospitalized_for_Acute_Medical_Illness_A_Multicenter_Cluster-Randomized_Trial/3933156）。