胎儿乳糜胸全基因组基因表达分析数据集

数据集获取（Figshare）

• 源站标题：Genome-Wide Gene Expression Analysis Implicates the Immune Response and Lymphangiogenesis in the Pathogenesis of Fetal Chylothorax
• DOI：10.1371/journal.pone.0034901
• 发布日期：2012-04-18
• 文件数：3 个
• 文件总体积：9.83 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Genome_Wide_Gene_Expression_Analysis_Implicates_the_Immune_Response_and_Lymphangiogenesis_in_the_Pathogenesis_of_Fetal_Chylothorax/126346

命令行下载

curl -L -o "Appendix_S1.pdf" "https://ndownloader.figshare.com/files/335856"
curl -L -o "Appendix_S2.rar" "https://ndownloader.figshare.com/files/336104"
curl -L -o "Appendix_S3.pdf" "https://ndownloader.figshare.com/files/336148"

文件清单

• Appendix_S1.pdf（7.19 MB）
• Appendix_S2.rar（2.57 MB）
• Appendix_S3.pdf（71.06 KB）

文件总体积 9.83 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Fetal chylothorax (FC) is a rare condition characterized by lymphocyte-rich pleural effusion. Although its pathogenesis remains elusive, it may involve inflammation, since there are increased concentrations of proinflammatory mediators in pleural fluids. Only a few hereditary lymphedema-associated gene loci, e.g. VEGFR3, ITGA9 and PTPN11, were detected in human fetuses with this condition; these cases had a poorer prognosis, due to defective lymphangiogenesis. In the present study, genome-wide gene expression analysis was conducted, comparing pleural and ascitic fluids in three hydropic fetuses, one with and two without the ITGA9 mutation. One fetus (the index case), from a dizygotic pregnancy (the cotwin was unaffected), received antenatal OK-432 pleurodesis and survived beyond the neonatal stage, despite having the ITGA9 mutation. Genes and pathways involved in the immune response were universally up-regulated in fetal pleural fluids compared to those in ascitic fluids. Furthermore, genes involved in the lymphangiogenesis pathway were down-regulated in fetal pleural fluids (compared to ascitic fluid), but following OK-432 pleurodesis, they were up-regulated. Expression of ITGA9 was concordant with overall trends of lymphangiogenesis. In conclusion, we inferred that both the immune response and lymphangiogenesis were implicated in the pathogenesis of fetal chylothorax. Furthermore, genome-wide gene expression microarray analysis may facilitate personalized medicine by selecting the most appropriate treatment, according to the specific circumstances of the patient, for this rare, but heterogeneous disease.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0034901（source: https://plos.figshare.com/articles/dataset/Genome_Wide_Gene_Expression_Analysis_Implicates_the_Immune_Response_and_Lymphangiogenesis_in_the_Pathogenesis_of_Fetal_Chylothorax/126346）。