中国捐赠者人类视网膜单细胞转录组图谱
中国捐赠者视网膜单细胞转录组图谱，涵盖约29万个细胞的10种主要细胞类型及亚型，揭示人群特异性细胞多样性与视网膜生物学机制。
基本信息
资源简介
中国捐赠者人类视网膜单细胞转录组图谱
【一句话概览】
本数据集是 figshare 公开的组学数据集，收录 55 个文件、合计 2.34 GB，主题涵盖 Single-cell RNA sequencing、Cell atlas、Chinese human retina，可用于生物标志物发现与分子分型研究，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《Single-cell transcriptomic atlas of human retina from Chinese donors reveals population-specific cellular diversity》。源站首次发布：2025-12-17。
【数据内容】
源站原始描述：The human retina exhibits complex cellular heterogeneity which is critical for visual function, yet comprehensive ethnic-specific references are scarce in ophthalmic transcriptomics. The lack of single-cell RNA sequencing (scRNA-seq) data from Asian populations particularly Chinese donors imposes significant limitations in understanding population-specific retinal biology. We constructed the first comprehensive single-cell transcriptomic atlas of the human retina from Chinese donors, generated t…
中文译文（机器翻译，仅供快速理解，请以原文为准）：人类视网膜表现出复杂的细胞异质性，这对视觉功能至关重要，但在眼科转录组学中，全面的
文件 README 为文本内容，开头为：README Single-cell Transcriptomic Atlas of Human Retina from Chinese Donors Dataset Description This repository contains single-cell RNA sequencing (scRNA-s…
【数据结构与技术规格】
文件数 55 个，合计 2.34 GB。README：text/plain，2.58 KB。features.tsv.gz：text/plain，333.44 KB。barcodes.tsv.gz：application/gzip，55.69 KB。数据集 DOI：10.6084/m9.figshare.28602647.v3。
【主题与分类】
源站学科分类：Genomics and transcriptomics。主题标签：Single-cell RNA sequencing、Cell atlas、Chinese human retina。
【适用方向】
组学数据适用于生物标志物发现与分子分型相关建模研究。
【获取与许可】
源站页面：https://figshare.com/articles/dataset/_b_Single-cell_b_b_b_b_transcriptomic_b_b_b_b_atlas_of_human_retina_from_Chinese_donors_reveals_population-specific_cellular_diversity_b_/28602647
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Lin, Sen (2025). Single-cell transcriptomic atlas of human retina from Chinese donors reveals population-specific cellular diversity. figshare. Dataset
下载信息
注册下载
需要注册 Kaggle 账号并登录后下载，适合需要跟踪下载记录和使用 API 的用户。
暂未开放公开下载
无需注册即可直接获取公开样本或文档，适合快速预览和评估数据集质量。
免登录当前数据集主要来源为 Kaggle 公开托管，完整影像包建议通过原始链接或 Kaggle API 获取。
使用方式
数据集获取（Figshare）
- 源站标题：<b>Single-cell</b><b> </b><b>transcriptomic</b><b> </b><b>atlas of human retina from Chinese donors reveals population-specific cellular diversity</b>
- DOI：10.6084/m9.figshare.28602647.v3
- 发布日期：2025-12-17
- 文件数：55 个
- 文件总体积：2.34 GB
- 源站页面：https://figshare.com/articles/dataset/_b_Single-cell_b_b_b_b_transcriptomic_b_b_b_b_atlas_of_human_retina_from_Chinese_donors_reveals_population-specific_cellular_diversity_b_/28602647
命令行下载
curl -L -o "README" "https://ndownloader.figshare.com/files/60447782"
curl -L -o "features.tsv.gz" "https://ndownloader.figshare.com/files/60403574"
curl -L -o "barcodes.tsv.gz" "https://ndownloader.figshare.com/files/60403577"
curl -L -o "matrix.mtx.gz" "https://ndownloader.figshare.com/files/60403580"
curl -L -o "features.tsv.gz" "https://ndownloader.figshare.com/files/60403583"
curl -L -o "barcodes.tsv.gz" "https://ndownloader.figshare.com/files/60403586"
curl -L -o "matrix.mtx.gz" "https://ndownloader.figshare.com/files/60403589"
curl -L -o "features.tsv.gz" "https://ndownloader.figshare.com/files/60403595"
文件清单
README（2.58 KB）features.tsv.gz（333.44 KB）barcodes.tsv.gz（55.69 KB）matrix.mtx.gz（129.01 MB）features.tsv.gz（333.44 KB）barcodes.tsv.gz（58.43 KB）matrix.mtx.gz（69.15 MB）features.tsv.gz（333.44 KB）barcodes.tsv.gz（38.16 KB）matrix.mtx.gz（83.22 MB）features.tsv.gz（333.44 KB）matrix.mtx.gz（69.39 MB）barcodes.tsv.gz（36.17 KB）features.tsv.gz（333.44 KB）barcodes.tsv.gz（77.00 KB）matrix.mtx.gz（139.67 MB）features.tsv.gz（333.44 KB）barcodes.tsv.gz（87.64 KB）matrix.mtx.gz（146.30 MB）features.tsv.gz（333.44 KB）
文件总体积 2.34 GB（源站 API 实测）。
数据说明
The human retina exhibits complex cellular heterogeneity which is critical for visual function, yet comprehensive ethnic-specific references are scarce in ophthalmic transcriptomics. The lack of single-cell RNA sequencing (scRNA-seq) data from Asian populations particularly Chinese donors imposes significant limitations in understanding population-specific retinal biology. We constructed the first comprehensive single-cell transcriptomic atlas of the human retina from Chinese donors, generated through high-throughput scRNA-seq of ~290,000 viable cells obtained from 18 fresh retinal specimens (living donor and post-mortem specimens). Our multi-level analysis identified 10 distinct retinal cell types, encompassing all major neuronal lineages, Müller glia, astrocytes, microglia. Detailed subcluster analyses further revealed extensive heterogeneity, identifying distinct subtypes within several cell populations such as 7 amacrine cell subtypes and 14 bipolar cell subtypes. Concurrently, through systematic analysis of delineated subtype-specific molecular programs, we mapped their associated biological signaling pathways, functions, and mechanistic processes. This analysis explained the critical involvement of these subpopulations in core biological processes including synaptic organization, neurotransmission, and phototransduction cascades, potentially governing retinal homeostatic regulation and disease mechanisms. Single-cell transcriptomic atlas of the human retina from Chinese donors describes a comprehensive cellular landscape, encompassing major cell types and subtypes including neuronal, glial, and immune populations. This ethnic-specific atlas provided an important reference for understanding retinal development, cellular interaction and disease pathogenesis in Chinese populations, addressing a longstanding gap in ophthalmic transcriptomic resources.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.6084/m9.figshare.28602647.v3（source: https://figshare.com/articles/dataset/_b_Single-cell_b_b_b_b_transcriptomic_b_b_b_b_atlas_of_human_retina_from_Chinese_donors_reveals_population-specific_cellular_diversity_b_/28602647）。
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