121个遗传变异与2型糖尿病的关联

数据集获取（Figshare）

• 源站标题：The association of T2D with a set of 121 genetic variants
• DOI：10.6084/m9.figshare.19316045.v2
• 发布日期：2022-07-20
• 文件数：1 个
• 文件总体积：250.72 KB
• 源站页面：https://figshare.com/articles/dataset/GENOTYPE_FREQ_6_MZO_2022_xlsx/19316045

命令行下载

curl -L -o "GENOTYPE FREQ 6 MZO 2022.xlsx" "https://ndownloader.figshare.com/files/34305905"

文件清单

• GENOTYPE FREQ 6 MZO 2022.xlsx（250.72 KB）

文件总体积 250.72 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Type 2 Diabetes Mellitus (T2D) is classified as a multifactorial and polygenic disease. The search for T2D associated DNA variants is complex; population studies are essential to assess the genetic influence. Association of T2D with a set of 121 genetic variants (63 located in 37 genes and four intergenic regions, and 58 informative ancestry markers) was assessed in 442 subjects (262 cases and 180 controls) from Northeastern Mexico. The approach was made using different transmission models: dominant, recessive, and MLMM. Age, body mass index (BMI), and gender data were obtained and considered as cofactors (gene-environment (G × E) interaction) in a multi-locus genetic model, and the ORs were calculated. Genetic variants were classified as Regulatory Region Variants, Nonsense-mediated decay transcript variants, and Missense Variants. Thirteen genetic variants showed association (PRPTOR (rs12950541 p-32) and UCP3 (rs7930460 and rs1800849 p-16 and 4.64x 10-7, respectively) with the additive genetic model (MLMM). These results can contribute to understanding the role of genetic variants on the risk of developing T2D in the Northeastern Mexican mestizo population and support future studies to evaluate and validate as biomarkers to improve genetic assessment via precision medicine.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.19316045.v2（source: https://figshare.com/articles/dataset/GENOTYPE_FREQ_6_MZO_2022_xlsx/19316045）。