识别2型糖尿病降糖治疗的良好反应者

数据集获取（Figshare）

• 源站标题：Identifying Good Responders to Glucose Lowering Therapy in Type 2 Diabetes: Implications for Stratified Medicine
• DOI：10.1371/journal.pone.0111235
• 发布日期：2014-10-23
• 文件数：3 个
• 文件总体积：118.31 KB
• 源站页面：https://plos.figshare.com/articles/dataset/_Identifying_Good_Responders_to_Glucose_Lowering_Therapy_in_Type_2_Diabetes_Implications_for_Stratified_Medicine_/1220344

命令行下载

curl -L -o "Figure_S1.pptx" "https://ndownloader.figshare.com/files/1763534"
curl -L -o "Table_S1.docx" "https://ndownloader.figshare.com/files/1763535"
curl -L -o "Table_S2.docx" "https://ndownloader.figshare.com/files/1763536"

文件清单

• Figure_S1.pptx（89.39 KB）
• Table_S1.docx（15.16 KB）
• Table_S2.docx（13.76 KB）

文件总体积 118.31 KB（源站 API 实测）。

数据说明

Aims
Defining responders to glucose lowering therapy can be important for both clinical care and for the development of a stratified approach to diabetes management. Response is commonly defined by either HbA1c change after treatment or whether a target HbA1c is achieved. We aimed to determine the extent to which the individuals identified as responders and non-responders to glucose lowering therapy, and their characteristics, depend on the response definition chosen.
Methods
We prospectively studied 230 participants commencing GLP-1 agonist therapy. We assessed participant characteristics at baseline and repeated HbA1c after 3 months treatment. We defined responders (best quartile of response) based on HbA1c change or HbA1c achieved. We assessed the extent to which these methods identified the same individuals and how this affected the baseline characteristics associated with treatment response.
Results
Different definitions of response identified different participants. Only 39% of responders by one definition were also good responders by the other. Characteristics associated with good response depend on the response definition chosen: good response by HbA1c achieved was associated with low baseline HbA1c (pConclusions
The outcome of studies aiming to identify predictors of treatment response to glucose lowering therapy may depend on how response is defined. Alternative definitions of response should be considered which minimise influence of baseline glycaemia.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0111235（source: https://plos.figshare.com/articles/dataset/_Identifying_Good_Responders_to_Glucose_Lowering_Therapy_in_Type_2_Diabetes_Implications_for_Stratified_Medicine_/1220344）。