INS-1大鼠胰岛素瘤细胞的蛋白质组学分析：内质网应激效应及GLP-1受体激动剂Exenatide的保护作用

资源简介

INS-1大鼠胰岛素瘤细胞的蛋白质组学分析：内质网应激效应及GLP-1受体激动剂Exenatide的保护作用

【数据集背景】

本数据集源站标题为《Proteomic Analysis of INS-1 Rat Insulinoma Cells: ER Stress Effects and the Protective Role of Exenatide, a GLP-1 Receptor Agonist》。配套论文《Proteomic Analysis of INS-1 Rat Insulinoma Cells: ER Stress Effects and the Protective Role of Exenatide, a GLP-1 Receptor Agonist》发表于 PLOS ONE（2015），DOI：10.1371/journal.pone.0120536。源站首次发布：2015-03-20。

【数据内容】

源站原始描述：Beta cell death caused by endoplasmic reticulum (ER) stress is a key factor aggravating type 2 diabetes. Exenatide, a glucagon-like peptide (GLP)-1 receptor agonist, prevents beta cell death induced by thapsigargin, a selective inhibitor of ER calcium storage. Here, we report on our proteomic studies designed to elucidate the underlying mechanisms. We conducted comparative proteomic analyses of cellular protein profiles during thapsigargin-induced cell death in the absence and presence of exenat…

【数据结构与技术规格】

文件数 13 个，合计 2.21 MB。S1_Fig.pdf：application/pdf，366.18 KB。S2_Fig.pdf：application/pdf，288.20 KB。S3_Fig.pdf：application/pdf，76.40 KB。数据集 DOI：10.1371/journal.pone.0120536。

【主题与分类】

源站学科分类：Uncategorised。主题标签：Receptor Agonist Beta cell death、alteration、heat shock proteins、ER calcium storage、type 2 diabetes、ins、Rat Insulinoma Cells、glp、exenatide、beta cell death。

【适用方向】

源站学科分类标注为 Uncategorised。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Proteomic_Analysis_of_INS_1_Rat_Insulinoma_Cells_ER_Stress_Effects_and_the_Protective_Role_of_Exenatide_a_GLP_1_Receptor_Agonist_/1346660

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Kim, Mi-Kyung; Cho, Jin-Hwan; Lee, Jae-Jin; Son, Moon-Ho; Lee, Kong-Joo (2016). Proteomic Analysis of INS-1 Rat Insulinoma Cells: ER Stress Effects and the Protective Role of Exenatide, a GLP-1 Receptor Agonist. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。