糖尿病患者微量白蛋白尿筛查半定量法诊断准确性及成本效益数据集

数据集获取（Figshare）

• 源站标题：Can a semi-quantitative method replace the current quantitative method for the annual screening of microalbuminuria in patients with diabetes? Diagnostic accuracy and cost-saving analysis considering the potential health burden
• DOI：10.1371/journal.pone.0227694
• 发布日期：2020-01-21
• 文件数：11 个
• 文件总体积：1.83 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Can_a_semi-quantitative_method_replace_the_current_quantitative_method_for_the_annual_screening_of_microalbuminuria_in_patients_with_diabetes_Diagnostic_accuracy_and_cost-saving_analysis_considering_the_potential_health_burden/11674968

命令行下载

curl -L -o "pone.0227694.s001.docx" "https://ndownloader.figshare.com/files/21217569"
curl -L -o "pone.0227694.s002.docx" "https://ndownloader.figshare.com/files/21217572"
curl -L -o "pone.0227694.s003.docx" "https://ndownloader.figshare.com/files/21217575"
curl -L -o "pone.0227694.s004.docx" "https://ndownloader.figshare.com/files/21217578"
curl -L -o "pone.0227694.s005.docx" "https://ndownloader.figshare.com/files/21217581"
curl -L -o "pone.0227694.s006.docx" "https://ndownloader.figshare.com/files/21217584"
curl -L -o "pone.0227694.s007.docx" "https://ndownloader.figshare.com/files/21217587"
curl -L -o "pone.0227694.s008.docx" "https://ndownloader.figshare.com/files/21217590"

文件清单

• pone.0227694.s001.docx（16.89 KB）
• pone.0227694.s002.docx（17.10 KB）
• pone.0227694.s003.docx（17.81 KB）
• pone.0227694.s004.docx（15.31 KB）
• pone.0227694.s005.docx（15.59 KB）
• pone.0227694.s006.docx（192.31 KB）
• pone.0227694.s007.docx（208.50 KB）
• pone.0227694.s008.docx（327.58 KB）
• pone.0227694.s009.docx（287.18 KB）
• pone.0227694.s010.pdf（625.20 KB）
• pone.0227694.s011.pdf（104.83 KB）

文件总体积 1.83 MB（源站 API 实测）。

数据说明

Objectives
Diabetes is a global epidemic, and the high cost of annually and quantitatively measuring urine albumin excretion using the turbidimetric immunoassay is challenging. We aimed to determine whether a semi-quantitative urinary albumin-creatinine ratio test could be used as a screening tool for microalbuminuria in diabetic patients.
Methods
We assessed the diagnostic accuracy of the semi-quantitative method. The costs of false results in the semi-quantitative method were calculated based on the annual probability of disease progression analyzed through a systematic literature review and meta-analysis. The pooled long-term cost-saving effect of the semi-quantitative method compared with the quantitative test was assessed using a Markov model simulating a long-term clinical setting. Diagnostic accuracy and the cost-saving effect were also validated in an independent external cohort.
Results
Compared with the quantitative test, the semi-quantitative method had sensitivities of 93.5% and 81.3% and specificities of 61.4% and 63.1% in the overall sample of diabetic patients (n = 1,881) and in diabetic patients with eGFR ≥60 ml/min/1.73 m2 and a negative dipstick test (n = 1,110), respectively. After adjusting for direct and indirect medical costs, including the risk of disease progression, which was adjusted by the meta-analyzed hazard ratio for clinical outcomes, it was determined that using the semi-quantitative method could save 439.4 USD per person for 10 years. Even after adjusting the result to the external validation cohort, 339.6 USD could be saved for one diabetic patient for 10 years.
Conclusions
The semi-quantitative method could be an appropriate screening tool for albuminuria in diabetic patients. Moreover, it can minimize the testing time and inconvenience and significantly reduce national health costs.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0227694（source: https://plos.figshare.com/articles/dataset/Can_a_semi-quantitative_method_replace_the_current_quantitative_method_for_the_annual_screening_of_microalbuminuria_in_patients_with_diabetes_Diagnostic_accuracy_and_cost-saving_analysis_considering_the_potential_health_burden/11674968）。