CYP2C19基因分型用于危重患者质子泵抑制剂个性化应激性溃疡预防的推荐建议：表1
基于CYP2C19基因分型的危重患者质子泵抑制剂个性化应激性溃疡预防推荐表格。
基本信息
资源简介
CYP2C19基因分型用于危重患者质子泵抑制剂个性化应激性溃疡预防的推荐建议：表1
【一句话概览】
本数据集是 figshare 公开的结构化表格数据集，收录 1 个文件、合计 14.23 KB，主题涵盖 critical care、personalized therapy、stress ulcer prophylaxis、proton pump inhibitors、pharmacogenetics，可用于统计建模、特征工程与队列分析，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《Table_1_CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommendations Proposal.docx》。配套论文《Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis*》发表于 Critical Care Medicine（2017），DOI：10.1097/CCM.0000000000002461。源站首次发布：2022-07-11。
【数据内容】
源站原始描述：To this date, there are no recommendations for personalized stress ulcer prophylaxis (SUP) in critical care that would take the patient''s individual genetic predispositions into account. Of drugs used for this purpose, proton pump inhibitors (PPIs) are the first-choice drugs in intensive care unit patients. The degradation of proton pump inhibitors is mediated by cytochrome P450 (CYP) enzymes; in particular, CYP2C19 and, to a lesser extent, CYP3A4 are involved. Expression and metabolic activity…
【数据结构与技术规格】
文件数 1 个，合计 14.23 KB。Table_1_CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommenda.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，14.23 KB。数据集 DOI：10.3389/fmed.2022.854280.s002。
【主题与分类】
源站学科分类：Radiology and Organ Imaging、Foetal Development and Medicine、Obstetrics and Gynaecology、Primary Health Care、Medical and Health Sciences not elsewhere classified、Dermatology。主题标签：critical care、personalized therapy、stress ulcer prophylaxis、proton pump inhibitors、pharmacogenetics、gene polymorphism、poor metabolizer、ultra-rapid metabolizer。
【适用方向】
结构化表格数据可直接用于统计建模、特征工程与队列分析。
【获取与许可】
源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_CYP2C19_Gene_Profiling_as_a_Tool_for_Personalized_Stress_Ulcer_Prophylaxis_With_Proton_Pump_Inhibitors_in_Critically_Ill_Patients_-_Recommendations_Proposal_docx/20280750
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Linhartová, Petra Bořilová; Zendulka, Ondřej; Janošek, Jaroslav; Mlčůchová, Natálie; Cvanová, Michaela; Daněk, Zdeněk; et al. (2022). Table_1_CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommendations Proposal.d…
【使用注意】
· 源站最后修改于 2023-06-02，引用时请注意版本时效。
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使用方式
数据集获取（Figshare）
- 源站标题：Table_1_CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommendations Proposal.docx
- DOI：10.3389/fmed.2022.854280.s002
- 发布日期：2022-07-11
- 文件数：1 个
- 文件总体积：14.23 KB
- 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_CYP2C19_Gene_Profiling_as_a_Tool_for_Personalized_Stress_Ulcer_Prophylaxis_With_Proton_Pump_Inhibitors_in_Critically_Ill_Patients_-_Recommendations_Proposal_docx/20280750
命令行下载
curl -L -o "Table_1_CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommenda.docx" "https://ndownloader.figshare.com/files/36223389"
文件清单
Table_1_CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommenda.docx（14.23 KB）
文件总体积 14.23 KB（源站 API 实测）。
数据说明
To this date, there are no recommendations for personalized stress ulcer prophylaxis (SUP) in critical care that would take the patient’‘s individual genetic predispositions into account. Of drugs used for this purpose, proton pump inhibitors (PPIs) are the first-choice drugs in intensive care unit patients. The degradation of proton pump inhibitors is mediated by cytochrome P450 (CYP) enzymes; in particular, CYP2C19 and, to a lesser extent, CYP3A4 are involved. Expression and metabolic activity of, namely in, CYP2C19 is significantly affected by single nucleotide polymorphisms, the drug metabolization rate varies greatly from ultrarapid to poor and likely influences the optimal dosage. As these CYP2C19 predictive phenotypes via CYP2C19 haplogenotypes (rs12248560/rs4244285) can be relatively easily determined using the current standard equipment of hospital laboratories, we prepared a set of recommendations for personalized PPI-based stress ulcer prophylaxis taking into account the patient’'s CYP2C19 predictive phenotype determined in this way. These recommendations are valid, in particular, for European, American and African populations, because these populations have the high representations of the CYP2C19*17 allele associated with the overexpression of the CYP2C19 gene and ultrarapid degradation of PPIs. We propose the CYP2C19 gene profiling as a tool for personalized SUP with PPI in critically ill patients.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.3389/fmed.2022.854280.s002（source: https://frontiersin.figshare.com/articles/dataset/Table_1_CYP2C19_Gene_Profiling_as_a_Tool_for_Personalized_Stress_Ulcer_Prophylaxis_With_Proton_Pump_Inhibitors_in_Critically_Ill_Patients_-_Recommendations_Proposal_docx/20280750）。
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