成年小鼠中降钙素受体样受体暂时性缺失导致多器官淋巴管扩张的特征

资源简介

成年小鼠中降钙素受体样受体暂时性缺失导致多器官淋巴管扩张的特征

【数据集背景】

本数据集源站标题为《Characteristics of Multi-Organ Lymphangiectasia Resulting from Temporal Deletion of Calcitonin Receptor-Like Receptor in Adult Mice》。配套论文《Characteristics of Multi-Organ Lymphangiectasia Resulting from Temporal Deletion of Calcitonin Receptor-Like Receptor in Adult Mice》发表于 PLoS ONE（2012），DOI：10.1371/journal.pone.0045261。源站首次发布：2012-09-17。

【数据内容】

源站原始描述：Adrenomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl) and receptor activity modifying protein 2/3, are highly expressed in lymphatic endothelial cells and are required for embryonic lymphatic development. To determine the role of Calcrl in adulthood, we used an inducible Cre-loxP system to temporally and ubiquitously delete Calcrl in adult mice. Following tamoxifen injection, Calcrlfl/fl/CAGGCre-ER™ mice rapidly developed corneal edema and inflammation that w…

【数据结构与技术规格】

文件数 2 个，合计 3.10 MB。Figure_S1.tif：image/tiff，2.32 MB。Figure_S2.tif：image/tiff，786.41 KB。数据集 DOI：10.1371/journal.pone.0045261。

【主题与分类】

源站学科分类：Physiology、Cell Biology。主题标签：characteristics、multi-organ、lymphangiectasia、resulting、temporal、deletion、receptor-like、mice。

【适用方向】

源站学科分类标注为 Physiology、Cell Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Characteristics_of_Multi_Organ_Lymphangiectasia_Resulting_from_Temporal_Deletion_of_Calcitonin_Receptor_Like_Receptor_in_Adult_Mice/120017

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：L. Hoopes, Samantha; H. Willcockson, Helen; M. Caron, Kathleen (2016). Characteristics of Multi-Organ Lymphangiectasia Resulting from Temporal Deletion of Calcitonin Receptor-Like Receptor in Adult Mice. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。