小鼠心室在严重肥厚型心肌病和心力衰竭发展过程中的全局microRNA表达谱

资源简介

小鼠心室在严重肥厚型心肌病和心力衰竭发展过程中的全局microRNA表达谱

【数据集背景】

本数据集源站标题为《Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure》。配套论文《Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure》发表于 PLoS ONE（2012），DOI：10.1371/journal.pone.0044744。源站首次发布：2012-09-14。

【数据内容】

源站原始描述：MicroRNAs (miRNAs) regulate post-transcriptional gene expression during development and disease. We have determined the miRNA expression levels of early- and end-stage hypertrophic cardiomyopathy (HCM) in a severe, transgenic mouse model of the disease. Five miRNAs were differentially expressed at an early stage of HCM development. Time-course analysis revealed that decreased expression of miR-1 and miR-133a commences at a pre-disease stage, and precedes upregulation of target genes causal of ca…

【数据结构与技术规格】

文件数 4 个，合计 6.46 MB。Figure_S1.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，1.64 MB。Figure_S2.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，3.18 MB。Figure_S3.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，1.57 MB。数据集 DOI：10.1371/journal.pone.0044744。

【主题与分类】

源站学科分类：Biotechnology、Genetics、Microbiology。主题标签：microrna、profiling、ventricles、hypertrophic、cardiomyopathy。

【适用方向】

源站学科分类标注为 Biotechnology、Genetics、Microbiology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Global_MicroRNA_Profiling_of_the_Mouse_Ventricles_during_Development_of_Severe_Hypertrophic_Cardiomyopathy_and_Heart_Failure/119985

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：D. Bagnall, Richard; Tsoutsman, Tatiana; E. Shephard, Rhian; Ritchie, William; Semsarian, Christopher (2016). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。