ST段抬高型心肌梗死患者血小板反应性的性别差异：ON-TIME 3试验子分析

数据集获取（Figshare）

• 源站标题：Table_1_Sex Differences in Platelet Reactivity in Patients With ST-Elevation Myocardial Infarction: A Sub-Analysis of the ON-TIME 3 Trial.docx
• DOI：10.3389/fcvm.2021.707814.s001
• 发布日期：2021-10-04
• 文件数：1 个
• 文件总体积：21.55 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_Sex_Differences_in_Platelet_Reactivity_in_Patients_With_ST-Elevation_Myocardial_Infarction_A_Sub-Analysis_of_the_ON-TIME_3_Trial_docx/16727869

命令行下载

curl -L -o "Table_1_Sex Differences in Platelet Reactivity in Patients With ST-Elevation Myocardial Infarction: A Sub-Analysis of the ON-TIME 3 Trial.docx" "https://ndownloader.figshare.com/files/30967300"

文件清单

• Table_1_Sex Differences in Platelet Reactivity in Patients With ST-Elevation Myocardial Infarction: A Sub-Analysis of the ON-TIME 3 Trial.docx（21.55 KB）

文件总体积 21.55 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background: Fast and adequate platelet inhibition is one of the cornerstones in the treatment of patients with ST-elevation myocardial infarction (STEMI). The aim of this analysis is to examine sex differences in platelet inhibition in the acute treatment of STEMI patients.
Methods: Platelet reactivity units (PRU) and ticagrelor plasma concentrations of all patients in the ON-TIME 3 were compared according to sex. All patients were pre-treated with crushed ticagrelor, aspirin and heparin. Both univariable and multivariable analyses were performed.
Results: In this sub-analysis of the ON-TIME 3 trial, 195 STEMI patients, of which 58 female patients (29.7%) and 137 male patients (70.3%), were analyzed. PRU-values immediately post-PCI were not different in females [median 135 (IQR 47-228)] compared to males [160 (IQR 40-219), P = 0.92]. Ticagrelor plasma concentrations were higher in the females at the start of primary PCI [141 ng/mL (IQR 25-491) vs. 76 ng/mL (IQR 15-245), P = 0.049] and at 6 hours post-primary PCI [495 ng/mL (IQR 283-661) vs. 321 ng/mL (IQR 196-537), P = 0.001] compared to males. However, immediately post-primary PCI and at 1-hour post-primary PCI no significant differences in ticagrelor concentrations were seen between sexes. In multivariable analysis, sex was significantly associated with ticagrelor concentration (P = 0.04), but not with PRU (P = 0.93).
Conclusion: Effective platelet inhibition reached by crushed ticagrelor in STEMI patients was similar in both sexes. Females had similar or even higher ticagrelor plasma concentrations up to 6 hours post-primary PCI compared with males.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fcvm.2021.707814.s001（source: https://frontiersin.figshare.com/articles/dataset/Table_1_Sex_Differences_in_Platelet_Reactivity_in_Patients_With_ST-Elevation_Myocardial_Infarction_A_Sub-Analysis_of_the_ON-TIME_3_Trial_docx/16727869）。